Andrzej Joachimiak

Senior Fellow

Biography

Andrzej Joachimiak    Argonne Distinguished Fellow, Director of the Structural Biology Center and the Midwest Center for Structural Genomics at Biosciences Division, Argonne National Laboratory, Argonne, IL, USA, Professor, Senior Fellow at the Computational Institute and the Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.  Education - M.S., the University of Adam Mickiewicz, Poznan, 1974; Ph. D. the Institute of Bioorganic Chemistry, Poznan (Poland) 1980; Postdoctoral Fellow – the University of Chicago 1980-1982; D.Sc. the Institute of Biochemistry and Biophysics, Warsaw, 1991.   Andrzej Joachimiak is an expert in synchrotron-based X-ray crystallography and structural biology.  At Argonne, he has made significant contributions to the high-throughput crystallography using synchrotron radiation and the development of state-of-the-art facilities for macromolecular crystallography and protein characterization. The development and integration of the novel synchrotron beamlines, exploitation of the anomalous signal-based phasing methods in the third-generation environment and integration of hardware and software at the Structural Biology Center beamlines at the Advanced Photon Source contributed very strongly to the enhanced efficiency of such facilities worldwide.  Andrzej’s research has also contributed to methods development in protein expression and purification, crystallization and data collection using synchrotron radiation. The methods for phasing novel structures using X-ray crystallography have effectively reduced time and cost of structure determination. The contribution to high-throughput molecular biology and crystallography has also made a major impact on structural biology in the U.S. and globally as well. This encouraged the initiation of structural genomics and structural proteomics projects and also led to the determination of thousands of novel protein structures.  He has also made highly important contributions to the field of structural genomics. The Midwest Center for Structural Genomics and the Center for Structural Genomics of Infectious Diseases are highly successful NIH-funded programs. A number of technologies have been developed in the MCSG, including gene cloning and protein expression, new vectors for protein expression in bacteria, automated protein purification techniques, automated protein crystallization, robot-assisted crystal mounting and automated structure determination.  Andrzej’s fields of interest include structural biology using synchrotron radiation, enzymes specificity, protein-ligand interactions, protein-nucleic acid interactions and molecular chaperones.   Andrzej published over >300 peer reviewed manuscripts and book chapters, has >15,900 total citations, >2170 structures deposited in the PDB. He serves as editor of Journal of Structural and Functional Genomics, Protein Science and Protein & Cell.   Awards, Honors and Memberships  • Fellow of the American Association for the Advancement of Science  • Member of the American Crystallographic Association  • Member of Protein Society  • University of Chicago Award for Distinguished Performance  • Member European Academy of Sciences  • Member International Structural Genomics Organization Advisory Board  • Member Protein Data Bank Advisory Committee  • Arthur H. Compton Award, Advanced Photon Source  • Member Polish Academy of Arts and Sciences