Dan Nicolae

Senior Fellow

Biography

My major research interests are in the areas of statistical genetics and mathematical statistics. The problems I am studying are mainly motivated by applications to the genetics of complex diseases.

Statistical genetics problems of interest include likelihood applications to gene mapping, multi-locus models and testing for gene-environment interaction, linkage disequilibrium and fine mapping, methods for genome-wide association studies, measures of relative information in genetic studies.

The applications I work on focus on finding the genetic and environmental components of asthma and the inflammatory bowel disease. I am also interested in functional genomics and the analysis of gene expression data.

Mathematical statistics topics I am working on include Bayesian and frequentist ways of measuring the amount of missing data, artificial likelihoods in hypothesis testing, and Monte-Carlo integration.